The signs of HLA-B27 are important to identify because this genetic marker is often linked with autoimmune conditions. People who are HLA-B27 positive are more likely to develop issues like ankylosing spondylitis, reactive arthritis, and other joint-related problems.
If you notice the symptoms early, treatment becomes easier. Let’s look at the 10 major signs of HLA-B27 you should not ignore.
1. Chronic Back Pain
One of the most common signs of HLA-B27 is constant lower back pain. It usually gets worse when you rest and improves when you move.
2. Morning Stiffness
If your back or joints feel stiff for more than 30 minutes after waking up, it may be a warning sign. Morning stiffness is often linked with HLA-B27 conditions.
3. Swollen Joints
Swelling in the knees, hips, or ankles is another key symptom. Inflammation can make your joints painful and limit your movement.
4. Eye Inflammation (Uveitis)
Redness, blurred vision, or pain in the eyes can be caused by uveitis. This condition is strongly linked with HLA-B27 positivity.
5. Constant Fatigue
Tiredness and weakness are common signs. Even after rest, you may feel drained of energy.
6. Heel Pain
Pain in the heel or under the foot, also called enthesitis, is another common symptom in HLA-B27 patients.
7. Hip and Shoulder Pain
If you feel stiffness or pain in your hips and shoulders, it could point to ankylosing spondylitis, which is associated with HLA-B27.
8. Limited Spinal Movement
When your spine becomes less flexible, bending or twisting becomes difficult. This is a sign that the condition is progressing.
9. Skin Problems
Some people with HLA-B27 may develop psoriasis-like rashes. Skin irritation or red patches can also be linked with autoimmune disorders.
10. Family History
If your family has a history of arthritis, ankylosing spondylitis, or psoriasis, you may have a higher risk of being HLA-B27 positive.

Final Thoughts On Signs Of HLA-B27
Knowing the signs of HLA-B27 early can help in getting the right treatment. Ignoring the symptoms may lead to complications later.
👉 At Vedic Upchar, you can get expert Ayurvedic consultation for HLA-B27–related issues. Ayurveda helps in reducing inflammation, improving mobility, and strengthening your immunity naturally.
Take action today and protect your health with the right guidance.